Expression of Sox2, Oct4, and Nanog in Human Lung Cancer Non-small-cell

Background: Cancer stem cells are a subpopulation of tumor with self-renewal capacity that promote tumorigenesis, resistance to chemotherapy, and metastasis. Sox2, Oct4, Nanog three pluripotent transcription factors expressed in embryonic cancer cells. Materials Methods: This study aimed evaluate the expression Nanog, analyze their clinical significance human non-small-cell lung (NSCLC). Expression Oct4 was assayed tissues corresponding paracancerous from 30 patients NSCLC. RT-PCR used these genes. The correlation between genes parameters including disease stage, smoking, lymph node, subgroups (adenocarcinoma squamous) were analyzed. Results: All simultaneously 76.6% samples. A significant observed comparison (P<0.000). Sox2 gene had positive stage (Sox2 P=0.01, P=0.0007), while profile showed sex (P=0.0063), smoking (P=0.0253), stages (P=0.0003), type (P=0.0085). Conclusion: Evaluating NSCLC might have some implications for diagnosis prognosis; they be also promising treatment targets. correlations prognosis pathological features overexpression suggest is potential indicator early